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ING2 inhibitor of growth family member 2 [ Homo sapiens (human) ]

Gene ID: 3622, updated on 2-Nov-2024

Summary

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Official Symbol
ING2provided by HGNC
Official Full Name
inhibitor of growth family member 2provided by HGNC
Primary source
HGNC:HGNC:6063
See related
Ensembl:ENSG00000168556 MIM:604215; AllianceGenome:HGNC:6063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ING1L; p33ING2
Summary
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in ovary (RPKM 10.5), adrenal (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

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See ING2 in Genome Data Viewer
Location:
4q35.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (183505058..183512429)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (186847848..186855219)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (184426211..184433582)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:184404105-184404605 Neighboring gene vesicle transport through interaction with t-SNAREs 1B pseudogene 2 Neighboring gene ING2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:184430298-184430798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:184430799-184431299 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:184458658-184459224 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:184462205-184463000 Neighboring gene uncharacterized LOC101929996 Neighboring gene uncharacterized LOC105377580

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ING2 recruits histone methyltransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9. Goeman F, et al. Biochim Biophys Acta, 2008 Oct. PMID 18513492
  2. Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. Huang W, et al. J Am Chem Soc, 2007 May 23. PMID 17469822, Free PMC Article
  3. The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells. Chin MY, et al. Exp Cell Res, 2005 Apr 1. PMID 15748897
  4. A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2. Temel M, et al. Tumour Biol, 2015 Jun. PMID 25613071
  5. Nuclear ING2 expression is reduced in osteosarcoma. Han XR, et al. Oncol Rep, 2014 Nov. PMID 25190103

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis.
    Title: ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis.
  2. Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
    Title: Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
  3. Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma.
    Title: Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma.
  4. Findings provide evidence that ING2 is a direct target of miR92a.
    Title: miR‑92a contributes to cell proliferation, apoptosis and doxorubicin chemosensitivity in gastric carcinoma cells.
  5. Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
    Title: A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.
  6. ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis.
    Title: Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis.
  7. Results suggest that ING2 acts as a tumor suppressor in osteosarcoma.
    Title: Nuclear ING2 expression is reduced in osteosarcoma.
  8. It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor.
    Title: A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2.
  9. Decreased expression of ING2 gene is associated with non-small cell lung cancer.
    Title: Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients.
  10. It was concluded that ING2 not only plays an essential role in the growth and invasion of MGC-803 cells but also represents a potential approach to chemosensitization therapy in human gastric cancer.
    Title: Knockdown of inhibitor of growth protein 2 inhibits cell invasion and enhances chemosensitivity to 5-FU in human gastric cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding TAS
Traceable Author Statement
more info
 PubMed 
enables histone deacetylase regulator activity TAS
Traceable Author Statement
more info
 PubMed 
enables histone reader activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in male germ-line stem cell asymmetric division ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in male meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular senescence NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in seminiferous tubule development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Sin3-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Sin3-type complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
inhibitor of growth protein 2
Names
ING1Lp
inhibitor of growth 1-like protein
p32

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291959.2 → NP_001278888.1  inhibitor of growth protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001278888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in translation initiation from an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC107214, AK294310, BC030128
    UniProtKB/Swiss-Prot
    Q9H160
    Conserved Domains (2) summary
    cd15683
    Location:173 → 221
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:18 → 81
    ING; Inhibitor of growth proteins N-terminal histone-binding

  2. NM_001564.4 → NP_001555.1  inhibitor of growth protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB012853, AC107214, AK314000, BC030128
    Consensus CDS
    CCDS3833.1
    UniProtKB/Swiss-Prot
    B6ZDS1, O95698, Q9H160
    UniProtKB/TrEMBL
    B2RA15
    Related
    ENSP00000307183.3, ENST00000302327.4
    Conserved Domains (2) summary
    cd15683
    Location:213 → 261
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    cd16861
    Location:32 → 119
    ING_ING2; Inhibitor of growth (ING) domain of inhibitor of growth protein 2 (ING2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    183505058..183512429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531927.3 → XP_011530229.1  inhibitor of growth protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011530229.1

    Conserved Domains (2) summary
    cd15683
    Location:158 → 206
    PHD_ING2; PHD finger found in inhibitor of growth protein 2 (ING2)
    pfam12998
    Location:3 → 66
    ING; Inhibitor of growth proteins N-terminal histone-binding

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    186847848..186855219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349960.1 → XP_054205935.1  inhibitor of growth protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H160.2 GenPept UniProtKB/Swiss-Prot:Q9H160

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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